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Shanghai Newgenco Bioscience Co.,Ltd
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Insulin Sensitizer(Buckwheat seed Extract) |
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 Model Number |
NG-BE-1001 |
Latin Name: Fagopyrum esculenta Moech, Fagopyrum tatarium Moench
Part of the Plant Used: Seeds
Product Introduction
1. Insulin enters the blood circulation and acts on the various organs and tissues to regulate glucose metabolism. Insulin binds to its specific cell surface receptors, activates a complex signal transduction pathway, and eventually leads to the opening of cell surface channels that take up glucose from the blood stream. The end result is the lowering of the blood glucose level.
2. Any blockade or efficiency decrease in this signaling pathway will result in compromised insulin action, affecting insulin? ability to regulate blood glucose. This is called insulin resistance. To compensate the decreased insulin sensitivity, human body produces more and more insulin. This leads to hyperinsulinia. The sustained high insulin level in the blood has detrimental effects on other metabolic processes, such as lipid metabolism and sex hormone metabolism. The broad category of human diseases resulting from insulin resistance is called X Syndrome and includes diabetes, high blood pressure, obesity, stroke, PCOS, etc.
3. Researches carried out in the last two decades at various laboratories have indicated that inositol molecules, particularly D-chiro-inositol and Myo-inositol, are important mediators for insulin action.
4. D-chiro-inositol was found to be present in the urine and blood of normal people but absent or at much reduced level in those of Type 2 diabetic patients, suggesting that Type 2 diabetic patients may not produce enough Inositol A and therefore exhibit a decrease in insulin sensitivity.
5. Results from several laboratories have demonstrated that provision of D-chiro-inositol and Myo-inositol can effectively improve insulin action and lower blood glucose, insulin, and triglyceride levels.
6. We discovered that buckwheat seeds contains large amount of inositol derivatives. We have further developed a proprietary technology that easily and cost-effectively converts the derivatives to active inositol compounds and subsequently isolates the active compounds as a pharmaceutical preparation, which we named ?ewgenco TangZhiShu Capsule? The technology is appropriate for large-scale production. This technology was submitted out for patent application in China in 2001 and 2003, and granted in 2004 and 2005.
7. ?ewgenco TangZhiShu Capsule?went through all strict formalities of safety evaluation and medical examination (including animal test and human clinical test) according to the standard procedures set out by Chinese regulatory agencies in 2002-2003 and was approved for manufacturing by SFDA of China in 2004. It was extracted from natural buckwheat seeds and contains a new kind of insulin sensitizer?-Chiro-Inositol(DCI)&Myo-Inositol (MI) and demonstrated an excellent safety, efficacy profiles and dominant effect on patients with diabetes, hyperlipidemia, hypertension and obesity
8. ?ewgenco TangZhiShu Capsule?was manufactured in a GMP standard by our two patented techniques. We discovered that natural buckwheat (Fagopyrum esculentum Moench, Fagopyrum trtarium Moench) seeds contains large amount of a new important mediator for insulin action in the derivation type. We have further developed a proprietary technology that easily and cost-effectively converts the derivatives to active mediator compounds and subsequently isolates the active compounds as a dietary supplement /pharmaceutical preparation, which we named ?ewgenco TangZhiShu Capsule? This technology was submitted out for patent application in China in 2001, 2003 and granted in 2004, 2005.
Quality Specification
Total Chiro-Inositol ≥1700mg/100g
(D-chiro-inositol and Myo-inositol)
Total Flavones(Rutin as Standard) ≥460mg/100g
Water ≤9%
Ash ≤8.0%
Lead ≤2.0mg/kg
Arsenic ≤1.0 mg/kg
Mercury ≤0.3mg/kg
Physiological Functions
?educes Serum Glucose in Streptozotocin-Diabetic Rats and in Type 2 diabetes patients have been tested
?ominant effect on hyperlipidemia rats have been tested.
?eported good effect on PCOS, hypertension, obesity(we plan to test it)
Applications
1.Function food
2.Food additive
3.Pharmaceutical stuff
Safety
Superior safety profile with no side effect tested by animal experiments
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